The world's worst diseases S01 E06 Smittkoppor

In 1741, Isabelle and Mario enjoy themselves at a fancy masquerade ball together with the nobility, but unfortunately they get smallpox. At this time, the doctors have no idea how to cure smallpox so Isabelle and Mario have to put make-up over their large boils in an attempt to look healthy. Does it help or hinder them in the fight against the deadly disease?