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The film contains five stories set on desolate stretches of a desert highway. Two men on the run from their past, a band on its way to a gig, a man struggling to get home, a brother in search of his long-lost sister and a family on vacation are forced to confront their worst fears and darkest secrets in these interwoven tales.

An orphaned girl is rescued from a satanic ritual and taken to Saint Catherine Institute for homeless youth. There she will learn new skills while facing demons that stalk her.

Moira Cole endeavors to rebuild her shattered life after her family's murder at the hands of her deranged and obsessed cousin.

The Utah community of Santa Ynez is being terrorized by a mysterious black coupe that appears out of nowhere and begins running people down. After the car kills off the town sheriff, Captain Wade Parent is determined to stop the murderous driver.

A woman wakes up injured in a basement surrounded by corpses. To survive, she pretends to be dead while a grotesque ritual unfolds in the house above.

As an evil takes over the world beyond their front doorstep, the only protection for a mother and her twin sons is their house and their family’s protective bond.

A woman returns to her family home and discovers it to be inhabited by monsters.

On their way to Mexico, six students are stranded in a small town where years before a tragedy took place.

As a group of seniors celebrate their final college days at a smart house, the house's highly advanced AI system, Margaux, begins to take on a deadly presence of her own. A carefree weekend of partying turns into a dystopian nightmare as they realize Margaux's plans to eliminate her tenants one way or another. Time begins to run out as the group desperately tries to survive and outsmart the smart home.

Shortly after moving into a dark, brooding mansion, a psychologist and his co-workers are terrorized by a horrible evil being.