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Dr. Matthew Clark is the head of a state institution for intellectually disabled children. Jean Hansen, a former music teacher anxious to give her life some meaning, joins the staff of the hospital. Jean, who tries to shelter the children with her love, suspiciously regards Dr. Clark's stern training methods. She becomes emotionally involved with 12-year-old Reuben Widdicombe, who has been abandoned by his divorced parents.

Matilda Wormwood is an brilliant and intelligent little girl. Unfortunately, her parents, Harry and Zinnia, fail to see that fact. As time passes, she finally starts school and has a kind teacher, loyal friends, and a terrifying, sadistic headmistress. As she becomes fed up with the constant cruelty, she discovers she has a special gift that she just might be able to use to outwit the unruly adults around her.

Melody Brooks, a sixth grader with cerebral palsy, has a quick wit and a sharp mind, but because she is non-verbal and uses a wheelchair, she is not given the same opportunities as her classmates. When a young educator notices her student's untapped potential and Melody starts to participate in mainstream education, Melody shows that what she has to say is more important than how she says it.

When Ruth Matthews's husband is killed in a fall at an archaeological dig, her daughter Sally handles her father's death in a very odd manner. As Sally's condition worsens, Ruth takes her to see Jake, an expert in childhood autism. Jake attempts to bring Sally out of her mental disarray through traditional therapy methods, but Ruth takes a different route. She risks her own sanity by attempting to enter her daughter's mind and make sense of the seemingly bizarre things that Sally does, including building a wondrous house of cards

Anne and "Poppy" Rose have three quirky kids. Anne has a generous heart and the belief in the innocence of children. To the unhappy surprise of her husband she takes in the orphan Jane, a problem child who already tried to kill herself once.

Adam, a lonely man with Asperger's Syndrome, develops a relationship with his upstairs neighbor, Beth.

New York sportswriter Mack has spent years devising successful hook-up "plays" with her friends, but when she unexpectedly falls for one of her targets, she must learn what it takes to go from simply scoring to playing for keeps.

A 15-year-old girl incites chaos among her friends and a media frenzy when she accuses her drama teacher of sexual harassment.

In Harlem in 1987, Claireece "Precious" Jones is a 16-year-old African American girl born into a life no one would want. She's pregnant for the second time by her absent father, and at home she must wait hand and foot on her mother, an angry woman who abuses her emotionally and physically. School is chaotic and Precious has reached the ninth grade with good marks and a secret – she can't read.

Blair, a waitress in the kingdom of Gardania, realises that she strongly resembles the region's missing queen. She then gets to go to Princess Charm School and causes problems for the teacher.