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An Oxford Medical School graduate takes a position at a mental institution and soon becomes obsessed with a female mental patient, but he has no idea of a recent and horrifying staffing change.

Set in the changing world of the late 1960s, Susanna Kaysen's prescribed "short rest" from a psychiatrist she had met only once becomes a strange, unknown journey into Alice's Wonderland, where she struggles with the thin line between normal and crazy. Susanna soon realizes how hard it is to get out once she has been committed, and she ultimately has to choose between the world of people who belong inside or the difficult world of reality outside.

A psychiatrist, whose client commits suicide, finds his family life disrupted after introducing her surviving brother to his wife and daughter.

A clinically depressed teenager gets a new start after he checks himself into an adult psychiatric ward.

A disconnected teenage girl enters a relationship with a man twice her age. She sees him as the solution to all her problems, but his intentions are not what they seem.

Zach Riley is a psychiatrist, who leaves a job at a prestigious university, to take up a job at the privately run mental institution, Millwood. What he doesn't reveal at the time of his appointment is that this was the very place where his novelist father, T.L. Pierson, spent many years of his life.

A troubled Southern man talks to his suicidal sister's psychiatrist about their family history and falls in love with her (and New York City) in the process.

A deranged man hides in the attic of a new house and becomes obsessed with the unsuspecting family that moves in.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

A petty criminal fakes insanity to serve his sentence in a mental ward rather than prison. He soon finds himself as a leader to the other patients—and an enemy to the cruel, domineering nurse who runs the ward.