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When car dealer Charlie Babbitt learns that his estranged father has died, he returns home to Cincinnati, where he discovers that he has a savant older brother named Raymond and that his father's $3 million fortune is being left to the mental institution in which Raymond lives. Motivated by his father's money, Charlie checks Raymond out of the facility in order to return with him to Los Angeles. The brothers' cross-country trip ends up changing both their lives.

Penny works at a supermarket and Phil is a gentle taxi-driver. Penny’s love for Phil has run dry and they lead joyless lives with their two children, Rachel, a cleaner, and Rory, who is unemployed and aggressive.

Tony Lip, a bouncer in 1962, is hired to drive pianist Don Shirley on a tour through the Deep South in the days when African Americans, forced to find alternate accommodations and services due to segregation laws below the Mason-Dixon Line, relied on a guide called The Negro Motorist Green Book.

The story of an old Jewish widow named Daisy Werthan and her relationship with her black chauffeur, Hoke. From an initial mere work relationship grew in 25 years a strong friendship between the two very different characters, in a time when those types of relationships were shunned.

Phillip is a wealthy quadriplegic who needs a caretaker to help him with his day-to-day routine in his New York penthouse. He decides to hire Dell, a struggling parolee who's trying to reconnect with his ex and his young son. Despite coming from two different worlds, an unlikely friendship starts to blossom.

Having suffered a tragedy, Ben becomes a caregiver to earn money. His first client, Trevor, is a hilarious 18-year-old with muscular dystrophy. One paralyzed emotionally, one paralyzed physically, Ben and Trevor hit the road on a trip into the western states. The folks they collect along the way will help them test their skills for surviving outside their calculated existence. Together, they come to understand the importance of hope and the necessity of true friendship.

Sylvia is a social worker who leads a simple and structured life: her daughter, her job, her AA meetings. This is blown open when Saul follows her home from their high school reunion. Their surprise encounter will profoundly impact both of them as they open the door to the past.

Rhode Island State Trooper Charlie Baileygates has a multiple personality disorder. One personality is crazy and aggressive, while the other is more friendly and laid back. Both of these personalities fall in love with the same woman named Irene after Charlie loses his medication.

Two drifters bum around, visit earthy women and discuss opening a car wash in Pittsburgh.

After ex-con Joe Braxton violates his probation, he is given a second chance. All he has to do is drive a group of special kids across the country.