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Agnes and her two sisters struggle through a day in a home overrun by gamblers, thieves, and johns.

A young heroin addict roams the streets of New York to panhandle and get her next fix, while her unstable boyfriend drifts in and out of her life at random.

The drug-induced utopias of four Coney Island residents are shattered when their addictions run deep.

When 13-year-old Tracy befriends Evie, the most popular girl in school, her life is turned upside down as Evie introduces her to a world of sex, drugs, and money. But it isn’t long before Tracy’s new lifestyle begins to take a heavy toll on her and her family.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

After he and his first wife separate, journalist David Sheff struggles to help their teenage son, who goes from experimenting with drugs to becoming devastatingly addicted to methamphetamine.

In the late 1990s, up-and-coming mixed martial artist Mark Kerr aspires to become the greatest fighter in the world. However, he must also battle his opioid dependence and a volatile relationship with his girlfriend Dawn.

A logger defends his family from a group of dangerous drug runners.

A recent widow invites her husband's troubled best friend to live with her and her two children. As he gradually turns his life around, he helps the family cope and confront their loss.