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In the film, Solo is a down-on-his-luck writer who is encouraged by his psychiatrist to get a dog. Solo meets his love interest, who he assumes to be a dog owner when meeting her at a dog play park, but dog problems stand in their way.

A writer for a greeting card company learns the true meaning of loneliness when he comes home to find his girlfriend in bed with another man.

Elizabeth, a charming morning show news anchor, seeks advice from her dog's therapist after a breakup. Tara, a spunky barista, dreams of a life beyond the coffee shop. Awkward Garrett pines for Tara while trying to keep his adopt-a-dog business afloat. Dax is a man-child and leader of the aspiring rock band Frunk. Grace and Kurt anxiously await the arrival of their adoptive daughter, Amelia. Walter, an aging, lonely widower, loses his dog Mabel when she runs off. The beloved canines in their lives soon start to influence their careers, friendships, and romantic relationships in funny and unexpected ways.

After a disastrous first date, wild-child Nicole and socially-anxious Max vow to lose each other’s numbers until they learn that their dogs found a love match, and now puppies are on the way! The hilariously mismatched Nicole and Max are forced to become responsible co-parents, but may end up finding love themselves.

A dog goes on quest to discover his purpose in life over the course of several lifetimes with multiple owners.

A woman's chaotic life becomes more complicated when she inherits her grandmother's dog.

Depressed and jaded after being dumped by her married boyfriend, aging beauty Minnie Moore wonders if she'll ever find love. After shaggy-haired parking lot attendant Seymour Moskowitz comes to her defense from an angry and rebuffed blind date, he falls hopelessly in love with her despite their myriad differences. Minnie reluctantly agrees to a date with Moskowitz, and, slowly but surely, an unlikely romance blossoms between the two.

A misanthropic author, a single mother and waitress, and a gay artist form an unlikely friendship after the artist is assaulted in a robbery.

Set in the year 2024 in post-apocalyptic America, 18-year old Vic and his telepathic dog, Blood, are scavengers in the desolate wilderness ravaged by World War IV, where survivors must battle for food and shelter in the desert-like wasteland. Vic and Blood eke out a meager existence, foraging for food and fighting gangs of cutthroats.

A girl, abandoned by her mother when she was three, moves to a small town in Florida with her father. There, she adopts an orphaned dog she names Winn-Dixie. The bond between the girl and her special companion brings together the people in a small Florida town and heals her own troubled relationship with her father.