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Grindhouse combines Robert Rodriguez's Planet Terror, a horror comedy about a group of survivors who battle zombie-like creatures, and Quentin Tarantino's Death Proof, an action thriller about a murderous stuntman who kills young women with modified vehicles. It is presented as a double feature with fictitious exploitation trailers preceding each segment.

A young, beautiful career woman rents a backwoods cabin to write her first novel. Attacked by a group of local lowlifes and left for dead, she devises a horrific plan to inflict revenge.

Crazed members of a sadistic family return to their childhood home to terrorize the new owners.

After years of separation, Irena Gallier and her minister brother, Paul, reunite in New Orleans. When zoologists capture a wild panther, Irena is drawn to the cat – and zoo curator Oliver to her. Soon, Paul will have to reveal the family secret: that when sexually aroused, they revert into predatory jungle cats.

As he helps a young artist with her upcoming exhibition, the owner of a mannequin shop's deadly, suppressed desires come to the surface.

Three American college students studying abroad are lured to a Slovakian hostel, and discover the grim reality behind it.

In a world where no one speaks, a devout female hunts down a young woman who has escaped her imprisonment. Recaptured by its ruthless leaders, Azrael is due to be sacrificed to pacify an ancient evil deep within the surrounding wilderness.

Nothing is what it seems when a twisted one-night stand spirals into a serial killer’s vicious murder spree.

Within the decadent walls of the Frankenstein mansion, the Baron and his depraved assistant Otto have discovered the means of creating new life. As the Baron's laboratory begins to fill up with stitched body parts, the Baroness dallies with the randy new manservant and soon the decadent, permissive household is consumed by an outrageous, bizarre and hilarious combination of death and dismemberment.

A woman wakes up injured in a basement surrounded by corpses. To survive, she pretends to be dead while a grotesque ritual unfolds in the house above.